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The tattooing process relates to the introduction of exogenous pigments that color the dermis in order to obtain a permanent, desired pattern. The complications associated with the tattooing process have been reported since the end of the 19th Century. Despite the prevalence of tattoos, public awareness of possible related complications and health risks is low. The exact pathogenesis of adverse tattoo reactions on functioning and microstructure of skin, still remains unknown. Potential local and systemic adverse reactions of the tattoos, as well as the reactions to the tattoo pigments used during this process, are inaccurately understood and poorly described. The aim of this study was to review the literature regarding skin complications after having a tattoo. This review of literature will allow the authors of this publication, to specify the aim of future studies, which will allow to precisely determine occurance of potential complications after having a tattoo.